POSTGRADUATE PROGRAM IN DEVELOPMENT AND TECHNOLOGICAL INNOVATION IN MEDICINES (PPgDITM)

FEDERAL UNIVERSITY OF PARAÍBA

 

 

 

Presentation

 

The Postgraduate Program in Development and Technological Innovation in Medicines (PPgDITM) is a Doctorate in Association (Concept 4), which aims to train human resources capable of acting in the research, development, and technological innovation of medicines. The PPgDITM proposal was based on the lack of doctoral courses in the area and of doctors with a profile to work in the industry, considering the growing installation of pharmaceutical chemicals, especially in the Northeast region of Brazil. Besides, there was a need to meet the demand generated by the opening of new undergraduate and master's courses in the area of Pharmacy in the North and Northeast regions, as the graduates of these courses did not have many options to continue their training in the region.

PPgDITM consists of a broad association of 4 IFES from the Northeast region: 1.Federal University of Ceará – UFC, 2.Universidade Federal da Paraíba – UFPB, 3.Federal Rural University of Pernambuco – UFRPE, 4.Universidade Federal do Rio Grande do Norte – UFRN. It was designed to cover all stages of the pharmaceutical production chain, involving aspects related to the development of drugs and medicines, the processes related to obtaining them, to use in the population, in the context of post-marketing surveillance and its interfaces, thus meeting the proposal to train qualified human resources, at the doctoral level.

To allow a broad training with a focus on the development of innovative medicines, the course is divided into thematic areas, called training stages. Each stage is made up of compulsory subjects (minimum of 18 credits) and electives (minimum of 18 credits), being planned in such a way that students take compulsory subjects in each of the training stages and then complement the credits with elective subjects according to the specificity of their thesis theme. Five training stages were structured, namely: Chemistry/Biochemistry, Non-clinical, Pharmaceutical, Clinic and Registration and Post-marketing, including Technological Innovation and Intellectual Property.

After the end of the course, the doctorate graduates of PPgDITM should have solid knowledge in the field of pharmacy, mastering the production chain for the development of new drugs and innovative research, and technology transfer in any of the stages of the chain: from synthesis

 

and prospecting for new bioactive molecules to the clinical research of new drugs, including determining the effectiveness and safety of these molecules and their formulation in pharmaceutical specialties.

 

 

 

Concentration area: Doctorate in TECHNOLOGICAL INNOVATION IN MEDICINES

 

 

 

Lines of Research:

 

• ANALYTICAL AND PRODUCTIVE TECHNOLOGIES

 

Development and application of innovative analytical technologies in the search for solutions of critical points in the production process, in the quality assessment of medicines and the obtainment of new bioactive molecules.

 

• PRE-CLINICAL AND CLINICAL TRIALS

 

Assessment of toxicity, pharmacological, and pharmacokinetic properties, and safety range for the treatment dose, as well as the optimization of pharmaceutical formulations and the assessment of biopharmaceutical, pharmacokinetic, and technological parameters.

 

• PRODUCT DEVELOPMENT AND PHARMACEUTICAL PROCESSES

 

Research and development of new products based on innovative drugs or technological changes aimed at improving the efficacy and safety of medicines. Research of new excipients and changes in formulations, processes, and products.

 

Curricular structure

 

1st STEP: CHEMISTRY AND BIOCHEMISTRY

 

Curricular component	Credit
Biopolymers	02
Biotechnology Applied to Medicines R&D	02
Chromatographic Methods Applied to the Development of Medicines	03
Research, Identification, and Characterization of New Therapeutic Targets	04
Natural Products as a Source of New Drugs	02
Proteomics	02
Medicinal Chemistry	04

 

 

2nd STEP: PHARMACEUTICAL

 

Curricular component	Credit
Biopharmaceutical Aspects Applied to R&D and Drug Registration	02
Good Manufacturing Practices	01
Pharmacotechnical Development and Phytotherapic Control	02
Drug Stability Study	01
Analytical Methodologies Applied to Chemical and Biological Matrices	04
Nanotechnology Applied to Drug Formulation	02
Preformulation of Pharmaceutical Forms	02
Pharmaceutical Form Technology	04
Synthetic Raw Materials Technology	04

 

 

3rd. STEP NON-CLINICAL

 

Curricular component	Credit
Experimental Assessment in Immediate Hypersensitivity Therapy	02
Biotransformation of Xenobiotics	03
Pre-clinical Pharmacological and Toxicological Trials	02
Experimental Oncology	04
Experimental Psychopharmacology	03

 

1. STEP CLINICAL

 

Curricular component	Credit
Clinical Assessment of Medicines	02
Clinical Pharmacokinetics	03
Topics in Pharmacotherapy	02
Post-Marketing Studies of Medicines	02

 

 

5th.STEP OF TECHNOLOGICAL INNOVATION AND INTELLECTUAL PROPERTY

 

Curricular component	Credit
Pharmaceutical Intellectual Property	04
Special Topics in Technological Innovation in Medicines	02

 

 

RELATED AREA

 

Curricular component	Credit
Biostatistics Applied to Medicines R&D	02
Research Ethics	01
Medicine R&D Seminars	01
Advanced Topics in Medicine R&D	02
Supercritical Technologies Applied to Natural Products	02
Scientific Article Writing	02
Pharmaceutical Stereochemistry	04
Organic Synthesis in Drug Procurement	04
Fundamentals of Spectrometric Analysis – Nuclear Magnetic Resonance	04
Advanced Topics in Medicine R&D II	03
Advanced Topics in Medicine R&D III	01
Advanced Topics in Medicine R&D IV	02
Advanced Topics in Medicine R&D V	02

 

 

The various components Advanced Topics in Medicine R&D aim to meet the growing demand, on the part of the course, of: conferences, lectures, seminars, and workshops, given by professors, renowned experts from the associated HEIs or visitors or by prominent professionals in the field, to encourage graduate students' knowledge on updated topics related to the program's concentration area and stimulate the development of scientific thinking, through discussions of the topics presented.